Research in medicine
Cardiovascular Disease Research, Transitional Research Interest: The differentiation of the use of multimodality imaging of the hibernating myocardium from scar tissue and the visualization of the effects of revascularization on myocardium with different amounts of scar tissue and hibernation. This anatomically delineates the circuits for ventricular tachycardia and fibrillation for isolation and ablation and prevention of VT, VF and SCD. Both dog and sheep models of myocardial infarction are used for the imaging.
Clinical Research Interest: Determination of the parameters that define VT initiation and maintenance after successful revascularization, including patient profile, cardiac risk, myocardium in jeopardy, comparison of MRI/CT/Echo/NST based viable myocardium.
Left Atrial Appendage Morphology and Atrial Fibrillation: Atrial fibrillation remains the most common arrhythmia in practice and stroke is one of the main killers and cause for morbidity worldwide. This current research garners the newly acquired knowledge of LAA morphology to determine the factors that induce thrombus formation in patients with atrial fibrillation leading to stroke.
Mind-Body Medicine: Includes research involving brain imaging, hormonal changes, immunological parameters in various states of consciousness and heart disease. Coronary artery disease is the most common killer in the Western Hemisphere. Factors studied include the role of emotions and environmental changes, including adverse environment, in precipitating and sustaining heart diseases. These include the role of meditation, stress reduction and biofeedback on the mind-heart axis to prevent and treat cardiovascular pathology initiated in a stressed organism.
- The use of Echo, CT and MRI in the delineation of hibernating, but live myocardium.
- Delineation of the anatomical pathway for VT ablation.
- The role of meditation in patients undergoing cardiac rehab in terms of mortality, morbidity, and MACE after STEMI.
- LAA morphology, epicardial fat and relation to atrial fibrillation.
- The role of meditation in sympathetic-parasympathetic modulation and TEE derived LAA velocity and the risk of stroke.
Research Faculty Positions Held:
Chief Research Mentor & Assistant Program Director Internal Medicine Residency Program & Member, Cardiology Research Board, Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine.
Instructor in Medicine, Division of Cardiology: In-charge of the Experimental EP Lab, Beth Israel Deaconess Medical Center.
The direction of the cardiovascular electrophysiology research lab involved research that spanned the use of animal models to delineate hibernating myocardium from dead myocardium and the clinical effects of revascularization. Different imaging modalities were used in sync, including MRI, voltage mapping, CT & nuclear imaging to detect living myocardium in chronic total occlusion. This research also investigated the effects of revascularization on myocardium with different amounts of scar tissue and hibernation. This involved the creation of a new sheep model of hibernating myocardium that is particularly useful for such studies, unlike the existing pig model. Additionally, the validation of the use of fractional QRS to determine myocardial viability for CTO was investigated. Both heart failure and ischemia models for the determination of the etiology of VT were created to see if they were amenable to revascularization or drug therapy.